NR2F6 Antibody, FITC conjugated | CSB-PA016058LC01HU
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NR2F6 Antibody, FITC conjugated | CSB-PA016058LC01HU | Cusabio
NR2F6 Antibody, FITC conjugated is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: NR2F6
Aliases: Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2), NR2F6, EAR2 ERBAL2
Background: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4 (+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC) .
Uniport ID: P10588
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Nuclear receptor subfamily 2 group F member 6 protein (6-194AA)
Immunogen Species: Human
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Epigenetics and Nuclear Signaling
Research Areas: Epigenetics & Nuclear Signaling