NELFB Antibody, Biotin conjugated | CSB-PA03765D0Rb

NELFB Antibody, Biotin conjugated | CSB-PA03765D0Rb | Cusabio

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Product Type: Polyclonal Antibody

Target Names: NELFB

Aliases: Negative elongation factor B (NELF-B) (Cofactor of BRCA1), NELFB, COBRA1 KIAA1182

Background: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. May be able to induce chromatin unfolding.

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: Q8WX92

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Negative elongation factor B protein (8-199AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling