NBN (Ab-343) Antibody | CSB-PA985787

NBN (Ab-343) Antibody | CSB-PA985787 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: NBN

Aliases: NBN

Background: Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Hsu HL, et al (2005) Oncogene; 24 (31) : 4956-64.
Falck J, et al. (2005) Nature; 434 (7033) : 605-11.
Buscemi G, et al. (2004) Oncogene; 23 (46) : 7691-700.
Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A; 101 (33) : 12130-5.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O60934

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Peptide sequence around aa.341~345 (S-L-S-Q-G) derived from Human p95/NBS1.

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200

Purification Method: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:1000

Dilution Ratio3: IHC:1:50-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling;Cancer