NANOG Monoclonal Antibody | CSB-MA888008A0m

NANOG Monoclonal Antibody | CSB-MA888008A0m | Cusabio

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Product Type: Monoclonal Antibody

Target Name: NANOG

Aliases: Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) , NANOG

Relevance: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768) . Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

Isotype: IgG1

Conjugate: Non-conjugated

Clone Number: 8A1D11

Uniport ID: Q9H9S0

Alternatives To SCBT: #N/A

Host Species: Mouse

Species Reactivity: Human, Mouse, Rat

Immunogen: Recombinant Human Homeobox protein NANOG protein (1-305AA)

Immunogen Species: Human

Applications: ELISA, WB, ICC, IF, FC

Tested Applications: ELISA, WB, ICC, IF, FC; Recommended dilution: WB:1:500-1:2000, ICC:1:50-1:500, IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: WB:1:500-1:2000

Dilution Ratio2: ICC:1:50-1:500

Dilution Ratio3: IF:1:50-1:200

Dilution Ratio4:

Dilution Ratio5:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Stem Cells

Research Areas: Stem Cells