Mmp13 Antibody | CSB-PA17739A0Rb

Mmp13 Antibody | CSB-PA17739A0Rb | Cusabio

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Product Type: Polyclonal Antibody

Target Names: Mmp13

Aliases: Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13), Mmp13

Background: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P33435

Host Species: Rabbit

Species Reactivity: Mouse

Immunogen: Recombinant Mouse Collagenase 3 protein (105-472AA)

Immunogen Species: Mouse

Applications: ELISA, IHC

Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:200-1:500

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cardiovascular

Research Areas: Cancer;Cardiovascular;Cell biology;Signal transduction