MEF2C Antibody | CSB-PA804958ESR2HU

MEF2C Antibody | CSB-PA804958ESR2HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: MEF2C

Aliases: Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C), MEF2C

Background: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity) . Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q06413

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Myocyte-specific enhancer factor 2C protein (170-380AA)

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Purification Method: Antigen Affinity Purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:20-1:200

Dilution Ratio3:

Dilution Ratio4:

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Dilution Ratio6:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Epigenetics & Nuclear Signaling;Neuroscience;Cardiovascular;Signal transduction;Stem cells