MCU Antibody, FITC conjugated | CSB-PA847694LC01HU

MCU Antibody, FITC conjugated | CSB-PA847694LC01HU | Cusabio

MCU Antibody, FITC conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: MCU

Aliases: Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A), MCU, C10orf42 CCDC109A

Background: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627) . Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363) . Activity is regulated by MICU1 and MICU2. At low Ca (2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca (2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221) . Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213) . While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276) . participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity) . Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870) . Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity) . Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity) . Involved in antigen processing and presentation (By similarity) .

Isotype: IgG

Conjugate: FITC

Clonality: Polyclonal

Uniport ID: Q8NE86

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Calcium uniporter protein, mitochondrial protein (155-233AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cardiovascular

Research Areas: Cardiovascular;Metabolism