MCU Antibody | CSB-PA847694LA01HU

MCU Antibody | CSB-PA847694LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: MCU

Aliases: Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A), MCU, C10orf42 CCDC109A

Background: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627) . Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363) . Activity is regulated by MICU1 and MICU2. At low Ca (2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca (2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221) . Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213) . While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276) . participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity) . Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870) . Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity) . Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity) . Involved in antigen processing and presentation (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q8NE86

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Calcium uniporter protein, mitochondrial protein (155-233AA)

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:5000

Dilution Ratio3: IHC:1:20-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cardiovascular

Research Areas: Cardiovascular;Metabolism