LGMN Antibody | CSB-PA012903LA01HU

LGMN Antibody | CSB-PA012903LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: LGMN

Aliases: Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1), LGMN, PRSC1

Background: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity) . May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q99538

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Legumain protein (199-312AA)

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:500-1:1000

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:500-1:1000

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Immunology

Research Areas: Cancer;Cell biology;Immunology;Metabolism;Signal transduction