KCNAB1 Antibody | CSB-PA012013LA01HU

KCNAB1 Antibody | CSB-PA012013LA01HU | Cusabio

KCNAB1 Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: KCNAB1

Aliases: Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K (+) channel subunit beta-1) (Kv-beta-1), KCNAB1, KCNA1B

Background: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368, PubMed:17540341, PubMed:19713757) . Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity) . Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity) . Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623) . Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757) . Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623) . Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368) . Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity) . Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764) . Enhances KCNB1 and KCNB2 channel activity (By similarity) . Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341) . Has NADPH-dependent aldoketoreductase activity (By similarity) . Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q14722

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Recombinant Human Voltage-gated potassium channel subunit beta-1 protein (287-401AA)

Immunogen Species: Human

Applications: ELISA, WB, IHC, IF

Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:5000

Dilution Ratio3: IHC:1:200-1:500

Dilution Ratio4: IF:1:50-1:200

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Neuroscience

Research Areas: Neuroscience