JAK3 Antibody | CSB-RA206737A0HU
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JAK3 Antibody | CSB-RA206737A0HU | Cusabio
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Antibody Type: Recombinant
Target Names: JAK3
Aliases: Tyrosine-protein kinase JAK3 (EC 188.8.131.52) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK), JAK3
Background: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Isotype: Rabbit IgG
Clone Number: 1C7
Uniport ID: P52333
Modified: Epigenetics and Nuclear Signaling; Cancer; Signal transduction
species: Homo sapiens (Human)
Species Reactivity: Human
Immunogen: A synthesized peptide derived from human JAK3
Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:50-1:200
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.