ITGA4 Antibody | CSB-PA977888

ITGA4 Antibody | CSB-PA977888 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: ITGA4

Aliases: IA4; MGC90518; ITGA4

Background: Integrins a-4/beta-1 (VLA-4) and a-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin a-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin a-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

Iida J., Meijne A.M.L., Oegema T.R. Jr. J. Biol. Chem. 273:5955-5962 (1998)
Liu S., Thomas S.M., Woodside D.G., Rose D.M. Nature 402:676-681 (1999)

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P13612

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Peptide sequence around aa.1024~1028 (Y-I-N-S-K) derived from Human LPAM-1 (Integrin a4, CD49d) .

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:1000

Purification Method: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:1000

Dilution Ratio3:

Dilution Ratio4:

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Dilution Ratio6:

Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Immunology

Research Areas: Cardiovascular;Immunology;Signal transduction;Stem cells