Cusabio Polyclonal Antibodies
IRAK4 Antibody | CSB-PA011812ESR1HU
- 3 to 7 Working Days
IRAK4 Antibody | CSB-PA011812ESR1HU | Cusabio
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Product Type: Polyclonal Antibody
Target Names: IRAK4
Aliases: Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 22.214.171.124) (Renal carcinoma antigen NY-REN-64), IRAK4
Background: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.
Uniport ID: Q9NWZ3
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Interleukin-1 receptor-associated kinase 4 protein (1-220AA)
Immunogen Species: Human
Applications: ELISA, WB, IP
Tested Applications: ELISA, WB, IP; Recommended dilution: WB:1:500-1:2000, IP:1:200-1:2000, IP:1:200-1:2000
Purification Method: Antigen Affinity Purified
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:2000
Dilution Ratio3: IP:1:200-1:2000
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Immunology
Research Areas: Cardiovascular;Immunology;Signal transduction