IGHG3 Antibody | CSB-PA011158OA01HU

IGHG3 Antibody | CSB-PA011158OA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: IGHG3

Aliases: Immunoglobulin heavy constant gamma 3 (HDC) (Heavy chain disease protein) (Ig gamma-3 chain C region), IGHG3

Background: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268) . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- (D) -J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P01860

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Peptide sequence from Human Immunoglobulin heavy constant gamma 3 protein (312-324AA)

Immunogen Species: Homo sapiens (Human)

Applications: ELISA, WB

Tested Applications: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

Purification Method: >95%, Protein G purified

Dilution Ratio1: WB:1:1000-1:5000

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Signal Transduction