HEY1 Antibody, Biotin conjugated | CSB-PA896909LD01HU

HEY1 Antibody, Biotin conjugated | CSB-PA896909LD01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: HEY1

Aliases: Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1), HEY1, BHLHB31 CHF2 HERP2 HESR1 HRT1

Background: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750) . Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867) . Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737) .

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: Q9Y5J3

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Hairy/enhancer-of-split related with YRPW motif protein 1 protein (200-300AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling;Cardiovascular