Cusabio Polyclonal Antibodies
HERC5 Antibody | CSB-PA883435LA01HU
- SKU:
- CSB-PA883435LA01HU
- Availability:
- 3 to 7 Working Days
Description
HERC5 Antibody | CSB-PA883435LA01HU | Cusabio
HERC5 Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: HERC5
Aliases: E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5), HERC5, CEB1 CEBP1
Background: Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: Q9UII4
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human E3 ISG15--protein ligase HERC5 protein (153-284AA)
Immunogen Species: Human
Applications: ELISA, IHC, IF
Tested Applications: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:20-1:200
Purification Method: >95%, Protein G purified
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: IHC:1:20-1:200
Dilution Ratio3: IF:1:20-1:200
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Immunology
Research Areas: Epigenetics & Nuclear Signaling;Cell biology;Immunology