Cusabio Polyclonal Antibodies
GRK6 Antibody | CSB-PA213352
- SKU:
- CSB-PA213352
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
GRK6 Antibody | CSB-PA213352 | Cusabio
GRK6 Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Product Type: Polyclonal Antibody
Target Names: GRK6
Aliases: EC 2.7.11.16; G-protein-coupled receptor kinase 6; GPRK6; kinase GRK6;
Background: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis By similarity. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro) .
Benovic J.L., J. Biol. Chem. 268:19521-19527 (1993) .
Haribabu B., Proc. Natl. Acad. Sci. U.S.A. 90:9398-9402 (1993) .
Stoffel R.H., J. Biol. Chem. 269:27791-27794 (1994) .
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: P43250
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from N-terminal of human GRK6.
Immunogen Species: Human
Applications: ELISA, WB, IF
Tested Applications: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500
Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:3000
Dilution Ratio3: IF:1:100-1:500
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Signal Transduction
Research Areas: Cardiovascular;Signal transduction