Cusabio Polyclonal Antibodies
GRIA3 Antibody | CSB-PA009900KA01HU
- SKU:
- CSB-PA009900KA01HU
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul (100ug)
Description
GRIA3 Antibody | CSB-PA009900KA01HU | Cusabio
GRIA3 Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: GRIA3
Aliases: GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3
Background: AMPA- (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainite- and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4) that assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Post-transcriptional modifications (alternative splicing and nuclear RNA editing) and post-translational modifications (glycosylation, phoshorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs. GluR 3 knockout mice exhibited normal basal synaptic transmission and long-term depression (LTD) but enhanced long-term potentiation (LTP) . In contrast, GluR 2/3 double knockout mice are impaired in basal synaptic transmission. Aberrant GluR 3 expression or activity is implicated in a number of diseases, including autoimmune epilepsy, X-linked mental retardation, Retts syndrome, amyotrophic lateral sclerosis and Alzheimer disease.
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: P42263
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human GRIA3
Immunogen Species: Human
Applications: ELISA, WB, IHC
Tested Applications: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200
Purification Method: Affinity purification
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:2000
Dilution Ratio3: IHC:1:50-1:200
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Neuroscience
Research Areas: Neuroscience;Signal transduction