GRHL3 Antibody, Biotin conjugated | CSB-PA844730LD01HU

GRHL3 Antibody, Biotin conjugated | CSB-PA844730LD01HU | Cusabio

GRHL3 Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: GRHL3

Aliases: Grainyhead-like protein 3 homolog (Sister of mammalian grainyhead) (Transcription factor CP2-like 4), GRHL3, SOM TFCP2L4

Background: Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity) . Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468) . xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity) . Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity) . Also required for proper development of the oral periderm (PubMed:24360809) . No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122) .

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: Q8TE85

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Grainyhead-like protein 3 homolog protein (31-182AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling