GPR18 Antibody | CSB-PA614525LA01HU

GPR18 Antibody | CSB-PA614525LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: GPR18

Aliases: N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18), GPR18, GPCRW

Background: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937) . However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161) . Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058) . The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083) . May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity) . Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity) . Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q14330

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Recombinant Human N-arachidonyl glycine receptor protein (290-331AA)

Immunogen Species: Human

Applications: ELISA, WB, IHC, IF

Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:2000

Dilution Ratio3: IHC:1:20-1:200

Dilution Ratio4: IF:1:50-1:200

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Neuroscience

Research Areas: Neuroscience;Signal transduction