GLRA1 Antibody | CSB-PA009516LA01HU

GLRA1 Antibody | CSB-PA009516LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: GLRA1

Aliases: Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit), GLRA1

Background: Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860) . Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272) . Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272) . Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753) . Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272) . Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488) . Channel activity is potentiated by ethanol (PubMed:25973519) . Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P23415

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Glycine receptor subunit alpha-1 protein (23-113AA)

Immunogen Species: Human

Applications: ELISA, WB, IHC, IF

Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:5000

Dilution Ratio3: IHC:1:20-1:200

Dilution Ratio4: IF:1:50-1:200

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Neuroscience

Research Areas: Neuroscience