Cusabio Recombinant Antibodies
FTO Antibody | CSB-RA880154A0HU
- 3 to 7 Working Days
FTO Antibody | CSB-RA880154A0HU | Cusabio
FTO Antibody is Available at Gentaur Genprice with the fastest delivery.
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Antibody Type: Recombinant Antibody
Target Names: FTO
Aliases: Alpha-ketoglutarate-dependent dioxygenase FTO, Fat mass and obesity-associated protein, FTO, KIAA1752
Background: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103). Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). In particular, it is involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746).
Isotype: Rabbit IgG
Clone Number: 4G9
Uniport ID: Q9C0B1
Species Reactivity: Human
Immunogen: A synthesized peptide derived from human FTO
Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.