Fhit Antibody | CSB-PA530819HA01MO

Fhit Antibody | CSB-PA530819HA01MO | Cusabio

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Product Type: Polyclonal Antibody

Target Names: Fhit

Aliases: Bis (5'-adenosyl) -triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Diadenosine 5', 5'''-P1, P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein), Fhit

Background: Cleaves P (1) -P (3) -bis (5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P (1) -P (4) -bis (5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P (1) -P (3) -bis (5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity) . Functions as tumor suppressor.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O89106

Host Species: Rabbit

Species Reactivity: Mouse

Immunogen: Recombinant Mouse Bis (5'-adenosyl) -triphosphatase protein (2-150AA)

Immunogen Species: Mouse

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling;Cancer