Cusabio Recombinant Antibodies
FGFR2 Antibody | CSB-RA154582A0HU
- 3 to 7 Working Days
FGFR2 Antibody | CSB-RA154582A0HU | Cusabio
FGFR2 Antibody is Available at Gentaur Genprice with the fastest delivery.
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Antibody Type: Recombinant
Target Names: FGFR2
Aliases: Fibroblast growth factor receptor 2 (FGFR-2) (EC 188.8.131.52) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332), FGFR2, BEK KGFR KSAM
Background: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Isotype: Rabbit IgG
Clone Number: 2,00E+09
Uniport ID: P21802
Modified: Neuroscience; Cancer; Cardiovascular; Developmental biology; Signal transduction; Stem cells
species: Homo sapiens (Human)
Species Reactivity: Human, Mouse, Rat
Immunogen: A synthesized peptide derived from human FGFR2
Tested Applications: ELISA, WB; Recommended dilution: WB:1:500-1:5000
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.