FEN1 Antibody | CSB-PA008585LA01DOA

FEN1 Antibody | CSB-PA008585LA01DOA | Cusabio

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Product Type: Polyclonal Antibody

Target Names: FEN1

Aliases: Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1, FEN1

Background: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinicapyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O65251

Host Species: Rabbit

Species Reactivity: Arabidopsis thaliana

Immunogen: Recombinant Arabidopsis thaliana Flap endonuclease 1 protein (85-383AA)

Immunogen Species: Arabidopsis thaliana (Mouse-ear cress)

Applications: ELISA, WB

Tested Applications: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:1000-1:5000

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling