Cusabio Polyclonal Antibodies
FEN1 Antibody, Biotin conjugated | CSB-PA008585LD01DOA
- 3 to 7 Working Days
FEN1 Antibody, Biotin conjugated | CSB-PA008585LD01DOA | Cusabio
FEN1 Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: FEN1
Aliases: Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1, FEN1
Background: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinicapyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Uniport ID: O65251
Host Species: Rabbit
Species Reactivity: Arabidopsis thaliana
Immunogen: Recombinant Arabidopsis thaliana Flap endonuclease 1 protein (85-383AA)
Immunogen Species: Arabidopsis thaliana (Mouse-ear cress)
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Epigenetics and Nuclear Signaling
Research Areas: Epigenetics & Nuclear Signaling