FBXO9 Antibody, HRP conjugated | CSB-PA891719LB01HU

FBXO9 Antibody, HRP conjugated | CSB-PA891719LB01HU | Cusabio

FBXO9 Antibody, HRP conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: FBXO9

Aliases: F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57), FBXO9, FBX9 VCIA1

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF (FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF (FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

Isotype: IgG

Conjugate: HRP

Clonality: Polyclonal

Uniport ID: Q9UK97

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human F-box only protein 9 protein (13-111AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Cell biology