DNMT1 Antibody, Biotin conjugated | CSB-PA007082HD01HU

(No reviews yet) Write a Review
SKU:
CSB-PA007082HD01HU
Availability:
3 to 7 Working Days
€315.80 - €488.70

Description

DNMT1 Antibody, Biotin conjugated | CSB-PA007082HD01HU | Cusabio

DNMT1 Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.

Online Order Payment is possible or send quotation to info@gentaur.com.

Product Type: Polyclonal Antibody

Target Names: DNMT1

Aliases: DNA (cytosine-5) -methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT), DNMT1, AIM CXXC9 DNMT

Background: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306) . Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306) . Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306) . Promotes tumor growth (PubMed:24623306) .

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: P26358

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human DNA (cytosine-5) -methyltransferase 1 protein (1288-1632AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

Dilution Ratio1:

Dilution Ratio2:

Dilution Ratio3:

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling

View AllClose

0 Reviews

View AllClose