Cusabio Polyclonal Antibodies
DNMT1 Antibody, Biotin conjugated | CSB-PA007082HD01HU
- SKU:
- CSB-PA007082HD01HU
- Availability:
- 3 to 7 Working Days
Description
DNMT1 Antibody, Biotin conjugated | CSB-PA007082HD01HU | Cusabio
DNMT1 Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: DNMT1
Aliases: DNA (cytosine-5) -methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT), DNMT1, AIM CXXC9 DNMT
Background: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306) . Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306) . Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306) . Promotes tumor growth (PubMed:24623306) .
Isotype: IgG
Conjugate: Biotin
Clonality: Polyclonal
Uniport ID: P26358
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human DNA (cytosine-5) -methyltransferase 1 protein (1288-1632AA)
Immunogen Species: Human
Applications: ELISA
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Epigenetics and Nuclear Signaling
Research Areas: Epigenetics & Nuclear Signaling