DKK3 Antibody | CSB-PA694792

DKK3 Antibody | CSB-PA694792 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: DKK3

Aliases: Dickkopf-related protein 3; Dkk-3; Dickkopf-3; hDkk-3;

Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease By similarity.

Shimizu K., Gene 282:151-158 (2002) .
Gray A.M., Genome Res. 13:2265-2270 (2003) .
Niehrs C., Oncogene 25:7469-7481 (2006) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q9UBP4

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Synthesized peptide derived from internal of human DKK3.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:3000

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

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Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Signal transduction;Stem cells