DKK1 Antibody | CSB-RA576260A0HU
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DKK1 Antibody | CSB-RA576260A0HU | Cusabio
DKK1 Antibody is Available at Gentaur Genprice with the fastest delivery.
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Antibody Type: Recombinant
Target Names: DKK1
Aliases: Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK), DKK1
Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Isotype: Rabbit IgG
Clone Number: 1D12
Uniport ID: O94907
Modified: Cardiovascular; Developmental biology; Immunology; Stem cells
species: Homo sapiens (Human)
Species Reactivity: Human
Immunogen: A synthesized peptide derived from human DKK1
Tested Applications: ELISA, WB; Recommended dilution: WB:1:500-1:5000
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.