Cusabio Polyclonal Antibodies
DIABLO Antibody, Biotin conjugated | CSB-PA865113LD01HU
- SKU:
- CSB-PA865113LD01HU
- Availability:
- 3 to 7 Working Days
Description
DIABLO Antibody, Biotin conjugated | CSB-PA865113LD01HU | Cusabio
DIABLO Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: DIABLO
Aliases: Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac), DIABLO, SMAC
Background: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) . Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Isotype: IgG
Conjugate: Biotin
Clonality: Polyclonal
Uniport ID: Q9NR28
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Diablo homolog, mitochondrial protein (168-236AA)
Immunogen Species: Human
Applications: ELISA
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Cell Biology
Research Areas: Cancer;Cell biology;Metabolism