DDB1 Monoclonal Antibody | CSB-MA202984

DDB1 Monoclonal Antibody | CSB-MA202984 | Cusabio

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Product Type: Monoclonal Antibody

Target Name: DDB1

Aliases: Damage specific DNA binding protein 1; Damage-specific DNA-binding protein 1; DDB 1; DDB p127 subunit; Ddb1; DDB1_HUMAN; DDBa; DNA damage binding protein 1; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1;

Relevance: Required for DNA repair.Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex) .The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair.The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD) , 6-4 photoproducts (6-4 PP) , apurinic sites and short mismatches.Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1.DCX (DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage.The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair.DCX (DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER.DCX (DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication.DCX (ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) .May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.

Isotype: IgG2b

Conjugate: Non-conjugated

Clone Number:

Uniport ID: Q16531

Alternatives To SCBT:

Host Species: Mouse

Species Reactivity: Human, Mouse, Rat, Monkey

Immunogen: Purified recombinant human DDB1 protein fragments expressed in E.coli.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;Recommended dilution:WB:1:500-1:5000

Purification Method: Affinity purified

Dilution Ratio1: WB:1:500-1:5000

Dilution Ratio2:

Dilution Ratio3:

Dilution Ratio4:

Dilution Ratio5:

Buffer: Ascites

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics and Nuclear Signaling