CXCR2 Antibody | CSB-PA282080
- 3 to 7 Working Days
CXCR2 Antibody | CSB-PA282080 | Cusabio
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Product Type: Polyclonal Antibody
Target Names: CXCR2
Aliases: chemokine (C-X-C motif) receptor 2
Background: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8) . It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
Uniport ID: P25025
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide of human CXCR2
Immunogen Species: Human
Applications: ELISA, WB
Tested Applications: ELISA, WB;ELISA:1:1000-1:2000, WB:1:200-1:1000
Purification Method: Antigen affinity purification
Dilution Ratio1: ELISA:1:1000-1:2000
Dilution Ratio2: WB:1:200-1:1000
Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Signal Transduction
Research Areas: Cell biology;Signal transduction