Cusabio Polyclonal Antibodies
CXCL8 Antibody, Biotin conjugated | CSB-PA08329D0Rb
- 3 to 7 Working Days
CXCL8 Antibody, Biotin conjugated | CSB-PA08329D0Rb | Cusabio
CXCL8 Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: CXCL8
Aliases: Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I) ; Interleukin-8 ( (Ala-IL-8) 77) (GCP/IL-8 protein II) (IL-8 (1-77) ) (IL8/NAP1 form II) (MDNCF-b) ; IL-8 (5-77) ; IL-8 (6-77) ( (Ser-IL-8) 72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF) ; IL-8 (7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV) ; IL-8 (8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V) ; IL-8 (9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI) ], CXCL8, IL8
Background: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Uniport ID: P10145
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Interleukin-8 protein (28-99AA)
Immunogen Species: Human
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Cardiovascular
Research Areas: Cancer;Cardiovascular;Immunology