CTH Antibody | CSB-PA006160LA01HU
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CTH Antibody | CSB-PA006160LA01HU | Cusabio
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Product Type: Polyclonal Antibody
Target Names: CTH
Aliases: Cystathionine gamma-lyase (EC 188.8.131.52) (Cysteine-protein sulfhydrase) (Gamma-cystathionase), CTH
Background: Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.
Uniport ID: P32929
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant Human Cystathionine gamma-lyase protein (1-70AA)
Immunogen Species: Human
Applications: ELISA, WB, IHC, IF
Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Purification Method: >95%, Protein G purified
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:5000
Dilution Ratio3: IHC:1:20-1:200
Dilution Ratio4: IF:1:50-1:200
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Signal Transduction
Research Areas: Cancer;Metabolism;Signal transduction