CST3 Monoclonal Antibody | CSB-MA061901A0m

CST3 Monoclonal Antibody | CSB-MA061901A0m | Cusabio

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Product Type: Monoclonal Antibody

Target Name: CST3

Aliases: CysC, Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin

Relevance: Defects in CST3 are the cause of amyloidosis type 6 (AMYL6) [MIM:105150]; also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA) , cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low.Genetic variations in CST3 are associated with age-related macular degeneration type 11 (ARMD11) [MIM:611953]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

Isotype: IgG2b

Conjugate: Non-conjugated

Clone Number: 3A1B7

Uniport ID: P01034

Alternatives To SCBT: sc-51857/sc-66100/sc-73878

Host Species: Mouse

Species Reactivity: Human

Immunogen: Recombinant Human Cystatin C protein

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC;Recommended dilution:IHC:1:50-1:500

Purification Method: >95%, Protein G purified

Dilution Ratio1: IHC:1:50-1:500

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Tags & Cell Markers

Research Areas: Cardiovascular;Cell biology;Tags & Cell Markers;Stem cells