CSK Monoclonal Antibody | CSB-MA199199

CSK Monoclonal Antibody | CSB-MA199199 | Cusabio

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Product Type: Monoclonal Antibody

Target Name: CSK

Aliases: C SRC; C SRC kinase; C src Tyrosine Kinase; C-SRC kinase; c-src tyrosine kinase; Csk A; CSK; CSK_HUMAN; CYTOPLASMIC TYROSINE KINASE; EC2.7.10.2; MGC112926; MGC117393; MGC154049; P60 Src; Protein tyrosine kinase CYL; Protein-tyrosine kinase CYL;

Relevance: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Isotype: IgG2b

Conjugate: Non-conjugated

Clone Number:

Uniport ID: P41240

Alternatives To SCBT:

Host Species: Mouse

Species Reactivity: Human, Rat

Immunogen: Purified recombinant human CSK protein fragments expressed in E.coli.

Immunogen Species: Human

Applications: ELISA, WB, ICC

Tested Applications: ELISA, WB, ICC;Recommended dilution:WB:1:500-1:5000, ICC:1:50-1:200

Purification Method: Affinity purified

Dilution Ratio1: WB:1:500-1:5000

Dilution Ratio2: ICC:1:50-1:200

Dilution Ratio3:

Dilution Ratio4:

Dilution Ratio5:

Buffer: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 0.1mg/mlBSA and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Signal transduction