Cusabio Polyclonal Antibodies
COPS2 Antibody | CSB-PA231077
- SKU:
- CSB-PA231077
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
COPS2 Antibody | CSB-PA231077 | Cusabio
COPS2 Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Product Type: Polyclonal Antibody
Target Names: COPS2
Aliases: ALIEN; COP9 constitutive photomorphogenic homolog subunit 2; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) ; COP9 signalosome complex subunit 2; CSN2
Background: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548 (2000) .
Lee J.W., Mol. Endocrinol. 9:243-254 (1995) .
Dressel U., Mol. Cell. Biol. 19:3383-3394 (1999) .
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: P61201
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from internal of human COPS2.
Immunogen Species: Human
Applications: ELISA, WB, IF
Tested Applications: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500
Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:3000
Dilution Ratio3: IF:1:100-1:500
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Signal Transduction
Research Areas: Epigenetics & Nuclear Signaling;Signal transduction