CLK2 Antibody | CSB-PA005558ESR2HU

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SKU:
CSB-PA005558ESR2HU
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3 to 7 Working Days
  • CLK2 Antibody
  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005558ESR2HU at dilution of 1:100
  • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA005558ESR2HU at dilution of 1:100
£184.00 - £253.68

Description

CLK2 Antibody | CSB-PA005558ESR2HU | Cusabio

CLK2 Antibody is Available at Gentaur Genprice with the fastest delivery.

Online Order Payment is possible or send quotation to info@gentaur.com.

Product Type: Polyclonal Antibody

Target Names: CLK2

Aliases: Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2), CLK2

Background: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P49760

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Dual specificity protein kinase CLK2 protein (240-499AA)

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Purification Method: Antigen Affinity Purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:20-1:200

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Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Epigenetics & Nuclear Signaling;Cell biology;Signal transduction

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