CLASP2 Antibody | CSB-PA005472LA01HU

CLASP2 Antibody | CSB-PA005472LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: CLASP2

Aliases: CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2), CLASP2, KIAA0627

Background: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921) . Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) . Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950) . This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514) . Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O75122

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human CLIP-associating protein 2 protein (226-381AA)

Immunogen Species: Human

Applications: ELISA, IHC, IP

Tested Applications: ELISA, IHC, IP; Recommended dilution: IHC:1:20-1:200, IP:1:200-1:2000

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:20-1:200

Dilution Ratio3: IP:1:200-1:2000

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Cell biology;Signal transduction