CDH1 Antibody | CSB-PA795479

CDH1 Antibody | CSB-PA795479 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: CDH1

Aliases: CDH1; CDHE; UVO

Background: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin a-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Baki L.et.al (2001) Proc. Natl. Acad. Sci. U.S.A. 98:2381-2386
Makagiansar I.T.et.al (2002) J. Biol. Chem. 277:16002-16010
Agiostratidou G. (2006) J. Neurochem. 96:1182-1188

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P12830

Host Species: Rabbit

Species Reactivity: Human, Mouse, Rat

Immunogen: Peptide sequence around aa.864~868 (E-W-G-N-R) derived from Human E-Cadherin.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:1000

Purification Method: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:1000

Dilution Ratio3:

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Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Cancer;Developmental biology;Signal transduction