CD31 Monoclonal Antibody | CSB-MA017767A0m
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CD31 Monoclonal Antibody | CSB-MA017767A0m | Cusabio
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Product Type: Monoclonal Antibody
Target Name: CD31
Aliases: Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, GPIIA', PECA1, CD31, PECAM1
Relevance: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308) . Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684) . Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308) . Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892) . Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892) . Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896) . Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896) . Induces susceptibility to atherosclerosis (By similarity) .
Clone Number: 9E6E12
Uniport ID: P16284
Alternatives To SCBT: #N/A
Host Species: Mouse
Species Reactivity: Human
Immunogen: Recombinant Human CD31 protein (28-315AA)
Immunogen Species: Human
Applications: ELISA, WB, IHC, IF, FC
Tested Applications: ELISA, WB, IHC, IF, FC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500, IF:1:50-1:200
Purification Method: >95%, Protein G purified
Dilution Ratio1: WB:1:500-1:5000
Dilution Ratio2: IHC:1:50-1:500
Dilution Ratio3: IF:1:50-1:200
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Cancer
Research Areas: Cancer;Cardiovascular;Immunology;Signal transduction;Stem cells