CD163 Monoclonal Antibody | CSB-MA942955

CD163 Monoclonal Antibody | CSB-MA942955 | Cusabio

CD163 Monoclonal Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Monoclonal Antibody

Target Name: CD163

Aliases: Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163) ], CD163, M130

Relevance: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

Isotype: IgG1, Kappa

Conjugate: Non-conjugated

Clone Number:

Uniport ID: Q86VB7

Alternatives To SCBT: #N/A

Host Species: Mouse

Species Reactivity: Human

Immunogen: Synthesized peptide derived from human CD163

Immunogen Species: Homo sapiens (Human)

Applications: ELISA, IHC

Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Purification Method: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Dilution Ratio1: IHC:1:20-1:200

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Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Immunology

Research Areas: Immunology