Cusabio Polyclonal Antibodies
CD163 Antibody | CSB-PA801238LA01HU
- 3 to 7 Working Days
CD163 Antibody | CSB-PA801238LA01HU | Cusabio
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Product Type: Polyclonal Antibody
Target Names: CD163
Aliases: Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163) ], CD163, M130
Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
Uniport ID: Q86VB7
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Scavenger receptor cysteine-rich type 1 protein M130 protein (801-940AA)
Immunogen Species: Homo sapiens (Human)
Applications: ELISA, IF
Tested Applications: ELISA, IF; Recommended dilution: IF:1:50-1:200
Purification Method: >95%, Protein G purified
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: IF:1:50-1:200
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Immunology
Research Areas: Cardiovascular;Immunology