CAV1 Antibody | CSB-PA004571OA01HU

CAV1 Antibody | CSB-PA004571OA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: CAV1

Aliases: Caveolin-1, CAV1, CAV

Background: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity) . Involved in the costimulatory signal essential for T-cell receptor (TCR) -mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed: 25893292) . Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed: 19262564) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q03135

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Peptide sequence from Human Caveolin-1 protein (26-43AA)

Immunogen Species: Human

Applications: ELISA, IF

Tested Applications: ELISA, IF; Recommended dilution: IF:1:50-1:200

Purification Method: Antigen Affinity Purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IF:1:50-1:200

Dilution Ratio3:

Dilution Ratio4:

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cardiovascular

Research Areas: Cancer;Cardiovascular;Tags & Cell Markers;Metabolism;Signal transduction