BMP10 Antibody | CSB-PA198870

BMP10 Antibody | CSB-PA198870 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: BMP10

Aliases: BMP-10; BMP10; Bone morphogenetic protein 10; MGC126783;

Background: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

Celeste A.J., Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Hillier L.W., Nature 434:724-731 (2005) .
Mazerbourg S., J. Biol. Chem. 280:32122-32132 (2005) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O95393

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Synthesized peptide derived from Internal of human BMP10.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:3000

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

Dilution Ratio3:

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Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Cardiovascular;Signal transduction