ARHGEF5 Antibody | CSB-PA618628LA01HU

ARHGEF5 Antibody | CSB-PA618628LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: ARHGEF5

Aliases: Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM), ARHGEF5, TIM

Background: Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624) . Strongly activates RHOA (PubMed:15601624) . Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity) . Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624) . Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653) . Required for SRC-induced podosome formation (By similarity) . Involved in positive regulation of immature dendritic cell migration (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q12774

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Rho guanine nucleotide exchange factor 5 protein (433-507AA)

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:20-1:200

Dilution Ratio3:

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Signal transduction