ALCAM Antibody | CSB-PA614444ESR1HU

ALCAM Antibody | CSB-PA614444ESR1HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: ALCAM

Aliases: CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166), ALCAM, MEMD

Background: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728) . Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728) . Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806) . Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806) . Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813) . Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771) . Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771) . Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity) . Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q13740

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human CD166 antigen protein (28-180AA)

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Purification Method: Antigen Affinity Purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:20-1:200

Dilution Ratio3:

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Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Immunology

Research Areas: Tags & Cell Markers;Immunology