ACER2 Antibody | CSB-PA293630

ACER2 Antibody | CSB-PA293630 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: ACER2

Aliases: Alkaline ceramidase 2; AlkCDase 2; Alkaline CDase 2; haCER2; EC=3.5.1.23

Background: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C (18:1) -, C (20:1) -, C (20:4) -ceramide > D-erythro-C (16:0) -, C (18:0), C (20:0) -ceramide > D-erythro-C (24:1) -ceramide > D-erythro-C (12:0) -ceramide, D-erythro-C (14:0) -ceramides > D-erythro-C (24:0) -ceramide > D-erythro-C (6:0) -ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.

Xu R., FASEB J. 20:1813-1825 (2006) [PubMed: 16940153].
Wan D., Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729 (2004) [PubMed: 15498874].
Humphray S.J., Nature 429:369-374 (2004) [PubMed: 15164053].

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q5QJU3

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Synthesized peptide derived from internal of human ASAH3L.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:3000

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

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Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Metabolism;Signal transduction